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Pathogenesis of PAH
 
 
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Clinical Classification of PAH
 
 
Diagnosis of PAH
 
Treatment of PAH
 
 
 
 
 
 
 
 
 
 
 
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Treatment of PAH
  • Treatment of PAH has historically been characterised by few and difficult options
    • anticoagulants to address thrombophilic predisposition of PAH
    • diuretics for treatment of right heart failure
    • oxygen to maintain oxygen saturation at > 90%
    • calcium-channel blockers (not licensed for PAH). Less than 10% of IPAH patients benefit from calcium-channel blocker therapy. This figure is even lower in the other forms of PAH.29
    • prostacyclin analogues can be challenging to administer
    • Inhibitors of phosphodiesterase-5 enzyme

Last update: 11 Jul 2008