The head office is located in Switzerland.

Actelion has local subsidiaries with commercial activities that cover the following territories:

Australia and New Zealand, Austria, Belgium and Luxembourg, Brazil, Canada, Czech and Slovak Republics, France, Germany, Greece, Italy, Japan, Korea (South), Netherlands, Portugal, Singapore, Spain, Switzerland, Turkey, United Kingdom and Republic of Ireland, United States of America and also in
China, Denmark , Finland, Hong Kong, Iceland, Israel,  Malaysia, Norway, Philippines, Romania, Saudia Arabia, Taiwan, Thailand through distribution partnerships.