Report of Actelion Management on Internal Control over Financial Reporting
Actelion’s Board of Directors and Management of the Group are responsible for establishing and maintaining adequate internal control over financial reporting. Actelion’s internal control system was designed to provide reasonable assurance to Actelion’s Management and Board of Directors regarding the reliability of financial reporting and the preparation and fair presentation of its published consolidated financial statements. All internal control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective may not prevent or detect misstatements and can provide only reasonable assurance with respect to financial statement preparation and presentation. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.Actelion Management assessed the effectiveness of the Group’s internal control over financial reporting as of December 31, 2006. In making this assessment, it used the criteria established within the Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Based on our assessment Management has concluded that, as of December 31, 2006, Actelion’s internal control over financial reporting is effective based on those criteria.
Management’s assessment of the effectiveness of internal control over financial reporting as of December 31, 2006 has been audited by Ernst & Young, Switzerland, an independent registered public accounting firm, as stated in their report which is included in this Annual Report.
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CEO CFO
Allschwil, February 16, 2007