THE ACTELION ANNUAL REPORT 2002
Notes to the Financial Statements 2002

1. Accounting principles
The financial statements of Actelion Ltd have been prepared in accordance with the accounting principles as prescribed by Swiss Company Law.
2. Material investments
Company Country Location Ownership Interest Function Share Capital
Actelion Pharmaceuticals Australia Pty Ltd
Australia

Sydney

100 %

Sales

AUD 2,016,667
Actelion Pharmaceuticals
Austria GmbH

Austria

Vienna

100 %

Sales

EUR 35,000
Actelion Pharmaceuticals
do Brasil Ltda

Brazil

Rio de Janeiro

100 %

Sales

BRL 376,444
Actelion Pharmaceuticals
Canada Inc

Canada

Laval

100 %

Sales

CAD 2,600,000
Actelion Pharmaceuticals
France SAS

France

Paris

100 %

Sales

EUR 200,000
Actelion Pharmaceuticals
Deutschland GmbH

Germany

Freiburg

100 %

Sales

EUR 1,000,000
Actelion Pharmaceuticals
Hellas SA

Greece

Chalandri

100 %

Sales

EUR 84,300
Actelion Pharmaceuticals
Italia S r l

Italy

Milan

100 %

Sales

EUR 15,000
Actelion Pharmaceuticals
Japan Ltd

Japan

Tokyo

100 %

Sales

JPY 95,000,000
Actelion Pharmaceuticals
Nederland BV

Netherlands

Hoofddorp

100 %

Sales

EUR 50,000
Actelion Pharmaceuticals
Espana SL

Spain

Barcelona

100 %

Sales

EUR 3,100
Actelion Pharmaceuticals
Sverige AB

Sweden

Danderyd

100 %

Sales

SEK 1,000,000
Actelion Pharmaceuticals Ltd (CH)





Switzerland



Allschwil



100 %
Research, Development, Production, Marketing


CHF 614,610
Actelion Pharmaceuticals UK Ltd
United Kingdom

London

100 %

Sales

EUR 250,000

Actelion Registration Ltd

United Kingdom

London

100 %
Holder marketing authorization EU
GBP 0
Actelion Pharmaceuticals US Inc
United States
South San Francisco
100 %

Sales

USD 5,000

Hesperion Ltd

Switzerland

Allschwil

69.1 %

Clinical research

CHF 140,000
Axovan AG Switzerland Allschwil 8.6 % Research CHF 1,875,490
3. Share capital
At December 31, 2002, the issued share capital amounts to CHF 53,441,398 consisting of 21,376,559 common shares (including 13,500 treasury shares) with a nominal value of CHF 2.50 each. The shares are registered and fully paid-up.
4. Conditional capital
Since inception the Company has created conditional capital for the stablishment of stock option plans, convertible bonds as well as for the potential issuance of shares in relation with certain credit facilities. At December 31, 2002 the Company has conditional capital of CHF 12,200,202.

Movements in conditional capital are as follows:
[CHF]  
January 1, 2001 12,314,700
Creation of conditional capital for Employee Stock Option Plans 500,000
Creation of conditional capital for convertible bonds/loans 780,000
Exercise of options and warrant (4,160,250)
December 31, 2001 9,434,450
Creation of conditional capital for Employee Stock Option Plans 1,250,000
Creation of conditional capital for convertible bonds/loans 2,120,000
Exercise of options (604,248)
December 31, 2002 12,200,202
5. Authorized capital
The Annual General Meeting of April 19, 2002 authorized the Company to create capital to be used for strategic purposes. The Board of Directors is authorized to increase until April 19, 2004 the share capital by an amount of not more than CHF 3,000,000 by issuance of not more than 1,200,000 fully paid-in registered shares with a nominal value of CHF 2.50 per share.
6. Treasury shares
During 2002 the Group bought 31,500 of its own shares with an average purchase price of CHF 73.11 and sold 18,000 shares with an average sales price of CHF 74.43. At December 31, 2002 the Group had 13,500 shares with an average purchase price of CHF 75.41.
7. Significant shareholders
According to the information available to the Board of Directors the following shareholders held a significant percentage of shares:


Name 2002 2001
Percentage of
share capital
Percentage of
voting rights
Percentage of share capital Percentage of voting rights
Management and Directors* 14.2** 14.2** 20.3 20.3
Rudolf Maag 6.6 6.6    
Deutsche Bank AG Nominees 5.0 5.0 6.2 5.0
Chase Nominees Ltd 8.4 5.0 6.2 5.0
OrbiMed Advisors 8.5 5.0 5.2 5.2
Biotech Invest SA 5.2 5.2 5.2 5.2

*No individual has a holding exceeding 5 %
**Total excluding Rudolf Maag



Proposed appropriation of available earnings

Available earnings 2002 2001
Retained earnings at the beginning of the year (1,880,636) 2,061,498
Net loss for the year (1,289,900) (3,942,134)
Total loss carried forward (3,170,536) (1,880,636)

Appropriation to general legal reserve
 
Balance to be carried forward (3,170,536) (1,880,636)